Johannes U. Mayer
Group Leader
I have always been intruiged by cell-cell interactions and cellular communication and signalling. To explore some of these interactions I worked on several research projects in Germany and abroad, such as the Helmholtz Center Munich, the ENS Lyon in France and the Rockefeller University in New York. I became really interested on how Dendritic cells within the intestine sense parasites and received a wellcome trust scholarship to study these responses at the University of Glasgow, UK, where I obtained my Master of Research (M.res.) degree in 2013 and my Ph.D. in Immunology in 2017.
To further work on this research question and investigate if the tissue environment could also directly influence the functional specialisation of dendritic cells in different organs I joined the Malaghan Institute of Medical Research in Wellington, New Zealand in 2017.
In 2021 I moved back to Germany to build my own research group at the Department of Dermatology and Allergology at the Philipps Universität Marburg, where my research focused on the role of different dendritic cell populations in the skin in health and disease. I was recently appointed Professor for Dermatological Immunotherapy at the Department of Dermatology of the University Medical Center Mainz where we are continueing our research efforts to understand the role of Dendritic Cells in chronic skin diseases and their interaction with other immune, stromal and epithelial cells.
Maximilian Sprang
Leading Bioinformatician/Junior group Leader
I was always fascinated by science from a small age and pursued the goal of being a scientist directly after school. I studied Biology as a Bachelor and switched to Applied Bioinformatics for the Master's. My PhD in Bioinformatics was focused on Quality Control for functional genomics and applied machine learning on such data. In my PostDoc phase with curATime and the TRR332, I worked on bioinformatic data analysis and developing machine learning applications for biomarker search in clinical and pre-clinical data.
During my PhD and PostDoc I was involved with the open source community and contributed and led projects focused on generative AI approaches for biosequences at OpenBioML.
In the Mayer group, I’ll be continuing with many of these projects and helping implement similar analyses in an immunological context. I will also be building my own junior research group focusing on bioinformatics and artificial intelligence for biomedicine and implementing new approaches to detect ealry stages of disease.
André Heinen
Flow Cytometry Specialist
My daily motivation is to learn and to improve medical treatments by making use of the most cutting-edge scientific methods. Starting my career in 2008, I became highly attracted to the enormously potential of flow cytometry. Subsequently, my expertise rapidly grew alongside technological progression. Beginning with the BD FACScan, I advanced to conducting experiments on nearly every BD platform, including cell sorting with the BD FACS Aria III or BD FACS Melody, and working with spectral-enabled devices like the BD FACSSymphony A5SE. Nowadays, in the Mayer Lab, the Cytek Aurora is my new companion for further learning. Another key area of expertise is my knowledge in implementing cutting-edge technologies and methodologies in complex working environments, both academic and corporate. In my last position at BioNTech SE, I implemented and managed the Flow Cytometry Core Facility.
Scientifically, my main background and interests are in investigating APC-T cell interactions. At the Mayer Lab, I aim to further deepen my scientific knowledge, as well as bridge the gap between wet-lab and dry-lab support, to enhance our expertise in flow cytometry and to support our colleagues in the best possible way with all kind of flow cytoemtry questions.
Tina Sarkar
PhD Student
I graduated from the Bachelor's of Health Sciences Honors program at the University of Calgary (UofC) in 2018, with a focus on biomedical sciences. I then decided to follow my love of immunology by completing a Master´s degree with the Paul Kubes Research group at UofC. After my time in academia I transitioned into a scientist role in the biotechnology industry where I worked at two different organizations focusing on cancer genetics and immunotherapeutics.
I have recently joined the Mayer Lab to pursue my PhD in Innate Lymphoid Cell biology and understanding the neuroimmune-axis that is present in the skin. I am thrilled to be doing some revolutionary science and my goal is to translate our findings to immunotherapies with my combined experience in the biotechnology industry.
Outside of the lab, I am an avid volunteer, love travelling and cooking nice meals with my partner Jonah!
Sunrito Mitra
PhD Student
Hello, I am Sunrito Mitra. I am really intrigued by understanding the impact of diseases on the immune system, which led me to pursue my bachelor's thesis on H. pylori-induced gastric cancer. However, working in a clinical setting, I realised the gap in fundamental research. That made me pursue a research-orientated masters at Ghent University in Belgium. During my master's, I worked on diverse topics but really got intrigued by the "hygiene hypothesis," which suggests that our immune system is impacted by the environment and diseases it encouters shifting industrialized countries to more severe immune disorders. This led me to pursue my master's thesis on macrophages in metabolic-dysfunction-associated steatotic liver disease (MASLD) at VIB-UGENT.
The desire to better grasp the immune system has led me to start my PhD at the lab of Prof. Johannes Mayer. I will be working on unravelling dendritic cell subsets in immunopriviledged organs such as the epididymis and testis. I look forward to the challenges ahead and becoming a well-rounded scientist.
Bingbing Chen
PhD Student
I have always been interested in immunology since my undergraduate studies at Jilin University, China. Not only because the immune system is important for our defence against external pathogens, but also because it represents an intricate network between different cells. In my undergraduate thesis, I focused on the effect of CD X on T cell activation by dendritic cells and its mechanism. To learn more about immunology from a different perspective, I pursed my Master's degree at the Institute of Biophysics, Chinese Academy of Science, focusing on the immune system and changes in metabolites related to the progression of pancreatic cancer.
To understand more about the interaction of metabolism and Dendritic cells, I joined the laboratory of Prof. Johannes Mayer as a PhD student. I look forward to the challenges ahead and am excited to dive into the field of immunometabolism.
Zhenfei Li
PhD Student
I am Zhenfei Li from China. During my master's studies, I focused on researching the correlation between skin tumors, such as squamous cell carcinoma (SCC), mycosis fungoides (MF) MF), Castleman’s disease (CD) CD), pyogenic granuloma (PG) and human herpesvirus 8. After graduation, I became a dermatologist in the Second People’s Hospital of Changzhi, dedicating myself to clinical work. In recent years, I have recognized certain deficiencies and gaps in my research knowledge. To better learn and innovate, I am fortunate to join Prof. Johannes Mayer's team and to do a PhD in his lab. While I feel lucky, I am also aware of the challenges ahead. I hope to complete my PhD through hard work and strive to become a clinician-scientist in the future.
Jeevan Mutha
PhD Student
During my bachelor’s studies in biotechnology, I learned about the brilliant research ideas and methodologies behind the attempts to decipher the complexity of the immune system. This inspired me to pursue immunological research as my primary research interest. My master’s thesis on human regulatory T cell plasticity at the KU Leuven allowed me to dive into these methods and address a complex immunological research question. This inspired me to study the fundamental nature of the immune system even in more detail.
In the Mayer lab, I will pursue my PhD primarily in studying the plasticity of Dendritic cells in context of tissue environment driven factors and apply this knowledge to build in vitro tissue-like systems. My goal for this duration is to constantly learn and enjoy the challenges involved in discovering new facts and features of the immune system.
Philipp Blöcher
Dr. med. Student
I am passionate about understanding the intricacies of the human body and why diseases develop. I therefore became a medical student at the University Medical Center Mainz. This journey began with a voluntary year at a hospital, which solidified my desire to study medicine.
Alongside my studies, I'm excited to be a medical doctoral student at the lab of Prof. Johannes Mayer. My work focuses on the fascinating realm of the innate immune system, particularly on very new aspects that focus on innate memory. My doctoral thesis will explore the changes in function and differentiation of dendritic cells and their progenitors during chronic infection to see if these changes play a long-term role on how we recognize pathogens. In my project I will use a 30-color full spectrum flow cytometry panel to profile the changes of innate and adaptive progenitor cells in the bone marrow and am excited about using this novel technology.
Emma Bökenkamp
Bachelor Student
I am studying Molecular Biology at Johannes Gutenberg University Mainz and have developed a deep interest in the complex mechanisms of the immune system during my studies. I am particularly fascinated by the role of dendritic cells as central mediators between innate and adaptive immunity.
As part of my bachelor's thesis at the Mayer Lab, I am focusing on the cultivation and analysis of various dendritic cell cell lines to determine their cell type and activation status. Using spectral flow cytometry, I am conducting detailed investigations into the functional activation and specialization of these cells. My goal is to gain a deeper understanding of their role in immunological processes and to provide new insights into medically relevant questions.
I hope with this work I can in a small part lay the foundation for innovative approaches in new avenues of research.