Dermatological Immunotherapy Group Mainz

Led by
Prof. Johannes U. Mayer

Email

johannes.mayer@unimedizin-mainz.de

Address

University Medical Center Mainz

Department of Dermatology

Bldg. 401

Langenbeckstrasse 1

55131 Mainz, Germany

Orcid https://orcid.org/0000-0001-6225-7803

X /JohannesUMayer

LinkedIn https://www.linkedin.com/in/johannesumayer/


"Our goal is to contribute to the understanding of early immune mechanisms that underlie common skin diseases and to identify how skin-specific Dendritic Cell populations shape these immune responses in a beneficial or detrimental way."


We have recently characterized the developmental requirements and functional role of a skin-specific population of dermal dendritic cells, which can be identified by their low expression of CD11b and develops in response to homeostatic levels of IL-13 in healthy skin (https://www.nature.com/articles/s41590-021-01067-0)

We now aim to understand the functional role of CD11b-low DC2 and other skin dendritic cells in health and disease using both pre-clinical models and patient samples. To gain a very detailed understanding of these cells and their function we are employing high-dimensional single cell technologies (like spectral flow cytometry, scRNAseq, scATACseq and spatial transcriptomics), as well as in vivo, in vitro and in situ tools to characterize how skin dendritic cells drive or dampen local and systemic immune responses and can be used as therapeutic targets for autoimmune, allergic diseases and cancer.

RECENT NEWS

05.11.2023

Our review article 'Tissue-specific antigen-presenting cells contribute todistinct phenotypes of allergy' together with Stefan Schülke, Stefanie Gilles and Adan C. Jirmo is now published at EJI onlinelibrary.wiley.com/doi/10.1002/eji.202249980 

29.09.2023

Johannes Mayer received his venia legendi (Habilitation) in Molecular Immunology from the Philipps Unviersity Marburg for his research into Tissue-specific Development and Function of Antigen-Presenting Cells.

04.09.2023

We have started to move parts of our Marburg laboratory to Mainz. Dr. Barbara Berg, Daniel Paul, Fabian Bleise and Benedikt Stegemann will remain in Marburg and new students will join us soon in Mainz.

01.09.2023

Johannes Mayer was appointed Professor for Dermatological Immunotherapy at the Department of Dermatology of the University Medical Center of the Johannes Gutenberg-University Mainz. A great achievement with many new opportunities.

31.05.2023

Daniel Paul, Benedikt Stegemann, Fabian Bleise and Tek Thakur got selected for poster presentations at the 11th UCT Science Day in Marburg on June 21st. What a great opportuntiy to present our work!


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