Dermatological and Computational Immunology Laboratory Mainz

Led by
Johannes U. Mayer

Professor in Dermatological ImmunotherapyDr. habil. in Molecular ImmunologyPhD in Advanced Immunology
Group Leader ‚Dermatological and Computational Immunology Laboratory‘Head of the High-Dimensional Spectral Flow Cytometry and Nanostring (HD-SCAN) Unit der Hautklinik

contact info

Address

University Medical Center Mainz

Department of Dermatology

Bldg. 401

Langenbeckstrasse 1

55131 Mainz, Germany

Orcid https://orcid.org/0000-0001-6225-7803

X /JohannesUMayer

LinkedIn https://www.linkedin.com/TheMayerLabMainz

"Unique Dendritic cell populations are located within specific tissue niches to fine-tune local immune responses. The goal of our lab is to understand their role in homeostasis, infection, inflammation and cancer, so that we can target and manipulate these mechanisms and guide new therapeutic strategies."

The fundamental role of Dendritic Cells is to screen tissues for pathogens. However, it is becoming more an more clear that they also take up signals from the local microenvironment and integrate these cues. We could show that these signals lead to local Dendritic cell differentiation and functionalization even in the absence of DC activation, suggesting that these populations perform an important auxillary role in the local niche. Our goal is to identify more and more of these local DC populations, leveraging our expertise in 30-color flow cytometry, single-cell sequencing and multiplex imaging and to understand how they contribute to local tissue maintanence. We are also interested in determining how skin inflammation, infection and cancer change the profile of these dendritic cells, perturb the microenvironment and lead to chronic or detrimental immunity. Furthermore, we believe that local infection/inflammation also affects Dendritic cells systemically and are actively investigating if Dendritic cell output or differentiation can be influenced within the bone marrow.

As part of the University Medical Center Mainz, the Research Center for Immunotherapy (FZI), the Center for Healthy Ageing (CHA) and the Institute for Quantitative and Computational Biosciences (IQCB) we want to develop novel treatment options to influence the local microenvironment and return it to homeostasis breaking chronic inflammatory cycles in skin inflammation and autoimmune disease.

Dermatological and Computational Immunology Laboratory Mainz

Led byJohannes U. Mayer

Led by
Johannes U. Mayer