Dermatological Immunotherapy Group Mainz
Led by
Prof. Johannes U. Mayer
johannes.mayer@unimedizin-mainz.de
Address
University Medical Center Mainz
Department of Dermatology
Bldg. 401
Langenbeckstrasse 1
55131 Mainz, Germany
"Our goal is to contribute to the understanding of early immune mechanisms that underlie common skin diseases and to identify how skin-specific Dendritic Cell populations shape these immune responses in a beneficial or detrimental way."
We have recently characterized the developmental requirements and functional role of a skin-specific population of dermal dendritic cells, which can be identified by their low expression of CD11b and develops in response to homeostatic levels of IL-13 in healthy skin (https://www.nature.com/articles/s41590-021-01067-0).
We now aim to understand the functional role of CD11b-low DC2 and other skin dendritic cells in health and disease using both pre-clinical models and patient samples. To gain a very detailed understanding of these cells and their function we are employing high-dimensional single cell technologies (like spectral flow cytometry, scRNAseq, scATACseq and spatial transcriptomics), as well as in vivo, in vitro and in situ tools to characterize how skin dendritic cells drive or dampen local and systemic immune responses and can be used as therapeutic targets for autoimmune, allergic diseases and cancer.
RECENT NEWS
05.11.2023
Our review article 'Tissue-specific antigen-presenting cells contribute todistinct phenotypes of allergy' together with Stefan Schülke, Stefanie Gilles and Adan C. Jirmo is now published at EJI onlinelibrary.wiley.com/doi/10.1002/eji.202249980
29.09.2023
Johannes Mayer received his venia legendi (Habilitation) in Molecular Immunology from the Philipps Unviersity Marburg for his research into Tissue-specific Development and Function of Antigen-Presenting Cells.
04.09.2023
We have started to move parts of our Marburg laboratory to Mainz. Dr. Barbara Berg, Daniel Paul, Fabian Bleise and Benedikt Stegemann will remain in Marburg and new students will join us soon in Mainz.
01.09.2023
Johannes Mayer was appointed Professor for Dermatological Immunotherapy at the Department of Dermatology of the University Medical Center of the Johannes Gutenberg-University Mainz. A great achievement with many new opportunities.
31.05.2023
Daniel Paul, Benedikt Stegemann, Fabian Bleise and Tek Thakur got selected for poster presentations at the 11th UCT Science Day in Marburg on June 21st. What a great opportuntiy to present our work!