Dermatological Immunotherapy Group Mainz
Led by
Johannes U. Mayer
Professor in Dermatological ImmunotherapyDr. habil. in Molecular ImmunologyPhD in Advanced Immunology
Address
University Medical Center Mainz
Department of Dermatology
Bldg. 401
Langenbeckstrasse 1
55131 Mainz, Germany
"We are fascinated by the ability of Dendritic Cells to fine-tune immune responses in the skin and other barrier sites and use omics technologies, such as 30-color flow cytometry, single-cell sequencing and multiplex imaging, to identify how we can manipulate these mechanisms to improve Dendritic Cell function in infection, inflammation and cancer."
It is being more and more appreciated that Dendritic Cells change their roles depending on the local microenvironment. They play important functions in tissue homeostasis, beneficial and detrimental immune responses and our lab leverages state-of-the-art technologies to understand and manipulate these heterogeneous functions.
As part of the University Medical Center Mainz, the Research Center for Immunotherapy (FZI), the Center for Healthy Ageing and the Institute for Quantitative and Computational Biosciences (IQCB) we aim to use our knowledge to idenfity and develop novel therapeutic approaches to improve Dendritic Cell function in infection, inflammation and cancer.
RECENT NEWS
11.04.2024
We have a met an exciting milestone and have started running our first 30-color full spectrum flow cytometry panels on our very own Cytek Aurora. There have been a lot of struggles getting to this point, but I am so proud of the team for getting us here! Expect some exciting data from the team soon.
07.03.2024
Our book chapter 'Immunophenotyping challenging tissue types using high-dimensional full spectrum flow cytometry' together with Laura Ferrer-Font, Olivia Brun and Kylie Price is now online at Methods in Cell Biology https://doi.org/10.1016/bs.mcb.2024.02.014
05.11.2023
Our review article 'Tissue-specific antigen-presenting cells contribute todistinct phenotypes of allergy' together with Stefan Schülke, Stefanie Gilles and Adan C. Jirmo is now published at EJI onlinelibrary.wiley.com/doi/10.1002/eji.202249980