DC Biology Lab Marburg

Led by
Dr. Johannes Mayer


Email johannes.mayer@uni-marburg.de

Address Department of Dermatology and Allergology

Philipps-Universität Marburg

Baldingerstraße

35043 Marburg, Germany

Orcid https://orcid.org/0000-0001-6225-7803

Twitter /JohannesUMayer

LinkedIn https://www.linkedin.com/in/johannesumayer/


"Our goal is to contribute to the understanding of early immune mechanisms that underly common skin diseases and to identify how skin-specific Dendritic Cell populations shape these immune responses in a beneficial or detrimental way."


We have recently characterized the developmental requirements and functional role of a skin-specific population of dermal dendritic cells, which can be identified by their low expression of CD11b and develops in response to homeostatic levels of IL-13 in healthy skin (https://www.nature.com/articles/s41590-021-01067-0).

We now aim to understand the functional role of CD11b-low DC2 and other skin dendritic cells in health and disease using both pre-clinical models and patient samples. We plan to deploy high-dimensional single cell technologies (like spectral flow cytometry, scRNAseq, scATACseq and spatial transcriptomics), as well as in vivo, in vitro and in situ tools to address how skin dendritic cells drive or dampen local and systemic immune responses and can be used as therapeutic targets for autoimmune, allergic diseases and cancer.

RECENT NEWS


01.07.2022 We welcome Neda Yaghoubi to our team, who will join us as a visiting PhD student from Iran for the next six months.

29.06.2022 Marie Witt presented her Bachelor project at the 10th UCT Science Day in Frankfurt and was selected for a flash talk. A great achievement!

20.05.2022 Congratulations to Dr. Johannes Mayer for being awarded the Theodor-Nasemann-Stipendium 2022, which he received at the 17. Benjamin von-Lipschütz Symposium in Düsseldorf.

01.05.2022 We are excited to welcome Dr. Mudassar Mughal from the University of Gießen to our team.

04.04.2022 Welcome to our medical PhD students Martin Salheiser and Fabian Bleise. It is great to have you with us!


Click here for more news!

Carousel imageCarousel imageCarousel imageCarousel imageCarousel imageCarousel imageCarousel imageCarousel imageCarousel imageCarousel imageCarousel imageCarousel imageCarousel imageCarousel image