Dermatological Immunotherapy Group Mainz
Led by
Prof. Johannes U. Mayer
Address
University Medical Center Mainz
Department of Dermatology
Bldg. 401
Langenbeckstrasse 1
55131 Mainz, Germany
"Our goal is to contribute to the understanding of early immune mechanisms that underlie common skin diseases and to identify how skin-specific Dendritic Cell populations shape these immune responses in a beneficial or detrimental way."
We have recently characterized the developmental requirements and functional role of a skin-specific population of dermal dendritic cells, which can be identified by their low expression of CD11b and develops in response to homeostatic levels of IL-13 in healthy skin (https://www.nature.com/articles/s41590-021-01067-0).
We now aim to understand the functional role of CD11b-low DC2 and other skin dendritic cells in health and disease using both pre-clinical models and patient samples. To gain a very detailed understanding of these cells and their function we are employing high-dimensional single cell technologies (like spectral flow cytometry, scRNAseq, scATACseq and spatial transcriptomics), as well as in vivo, in vitro and in situ tools to characterize how skin dendritic cells drive or dampen local and systemic immune responses and can be used as therapeutic targets for autoimmune, allergic diseases and cancer.
RECENT NEWS
11.04.2024
We have a met an exciting milestone and have started running our first 30-color full spectrum flow cyteomtry panels on our very own Cytek Aurora. There have been a lot of struggles getting to this point, but I am so proud of the team for getting us here! Expect some exciting data from Carolin, Philipp and Meghana soon.
07.03.2024
Our book chapter 'Immunophenotyping challenging tissue types using high-dimensional full spectrum flow cytometry' together with Laura Ferrer-Font, Olivia Brun and Kylie Price is now online at Methods in Cell Biology https://doi.org/10.1016/bs.mcb.2024.02.014
05.11.2023
Our review article 'Tissue-specific antigen-presenting cells contribute todistinct phenotypes of allergy' together with Stefan Schülke, Stefanie Gilles and Adan C. Jirmo is now published at EJI onlinelibrary.wiley.com/doi/10.1002/eji.202249980
29.09.2023
Johannes Mayer received his venia legendi (Habilitation) in Molecular Immunology from the Philipps Unviersity Marburg for his research into Tissue-specific Development and Function of Antigen-Presenting Cells.
14.09.2023
We have started to move laboratory to Mainz. Barbara Berg, Daniel Paul, Fabian Bleise and Benedikt Stegemann will remain in Marburg and new students will join us soon in Mainz.
01.09.2023
Johannes Mayer was appointed Professor for Dermatological Immunotherapy at the Department of Dermatology of the University Medical Center of the Johannes Gutenberg-University Mainz. A great achievement with many new opportunities.